Low Temperature Physics: 48, 311 (2022); https://doi.org/10.1063/10.0009735
Fizika Nizkikh Temperatur: Volume 48, Number 4 (April 2022), p. 351-358    ( to contents , go back )

Conformation impact in the deformation of DNA TATA-box

P. P. Kanevska and S. N. Volkov

Bogolyubov Institute for Theoretical Physics of the National Academy of Sciences of Ukraine, Kyiv 03143, Ukraine
E-mail: snvolkov@bitp.kiev.ua
pos Анотація:989

Received December 21, 2021, published online February 25, 2022

Abstract

The ability to undergo specific deformation in response to conformational changes of some sites of the macromolecule is the key element of DNA genetic activity regulation in biological cells. The deformation of the definite sequences in DNA chain provides an a ccurate reading of genetic information and the process of protein synthesis passing. The model based on the analysis of conformational changes of the TATA nucleotide sequence in DNA double helix is developed. In addition to elastic components (bending, twisting), the presented model includes the conformational rearrangements of the TATA-box. Obtained form, value, and energy of DNA cite deformation allow to offer the probable mechanism of recognition of key DNA sequences and makes it possible to explain the high accuracy of the processes of reproducing of genetic information in biological cells. The formulated physical mechanism of DNA deformation can be one of the main principles of genetic information realization.

Key words: DNA deformation, TATA-box, polymorphism, nonlinear mechanics.

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